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 Formulary Chapter 11: Eye - Full Chapter
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11.01  Administration of drugs to the eye
11.02  Control of microbial contamination
11.03  Anti-infective eye preparations
11.03.01  Antibacterials
Amikacin 2.5% eye drops
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Red

Unlicensed

 
   
Azithromycin (Azyter®)
(single use eye drops)
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Red
 
   
Benzylpenicillin
(eye drops)
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Red

Unlicensed special - Ophthalmology Only

 
   
Ceftazidime
(eye drops)
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Red

Unlicensed special - Ophthalmology only

 
   
Cefuroxime
(eye drops)
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Red

Unlicensed special - Ophthalmology only


 

 
   
Cefuroxime  (Aprokam®)
(intracameral injection)
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Red
Prophylaxis of endophthalmitis after cataract surgery 
   
Chlorhexidine digluconate 0.2% eye drops
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Red

Unlicensed

 
   
Ciprofloxacin
(eye drops and eye ointment)
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Amber Recommended
 
   
Erythromycin 0.5%
(eye ointment)
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Red

Unlicensed

 
   
Fusidic Acid 1%
(eye drops)
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Green

Second line

 
   
Gentamicin 0.3%
(eye drops)
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Green
 
   
Gentamicin 1.5%
(eye drops)
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Red
Unlicensed 
   
Levofloxacin
(eye drops)
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Red

 


Eye drops


Preservative free eye drops


 

 
   
Natamycin 5% eye drops
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Red

Unlicensed

 
   
Ofloxacin Eye drops (Exocin®)
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Amber Recommended

Severe bacterial infections

 

 

 
   
Polihexanide 0.02%
(eye drops)
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Red

Unlicensed

 
   
Propamidine Isetionate (Brolene® eye drops)
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Red

Acanthamoeba keratitis (unlicensed indication)

 
   
Vancomycin intravitreal injection
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Red

Unlicensed

 
   
Chloramphenicol
(eye drops and eye ointment)
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Restricted Drug Restricted
Green

NHS England low value medicine

A prescription for treatment of conjunctivitis should not be routinely offered in primary care as the condition is sel-limiting and will clear up on its own without the need for treatment

 

 

 
   
11.03.02  Antifungals to top
Amphotericin 0.15%
(eye drops)
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Restricted Drug Restricted
Red

Unlicensed - Ophthalmology only

 
   
Fluconazole 0.2% eye drops
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Red

Unlicensed

 
   
11.03.03  Antivirals
Aciclovir eye ointment 3% (Zovirax®)
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Green

This product will be discontinued. GSK anticipate supplies to be available until June 2019.

A suitable alternative is ganciclovir eye gel

 
   
Ganciclovir 0.15% ophthalmic gel (Virgan®)
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Green
 
   
Trifluorothymidine 1%
(eye drops)
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Red

Unlicensed - ophthalmology only

 
   
11.04  Corticosteroids and other anti-inflammatory preparations
11.04.01  Corticosteroids
Betamethasone 0.1% with Neomycin 0.5% eye drops (Betnesol N®)
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Green
 
   
Betamethasone eye drops
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Green
 
   
Betamethasone eye ointment (Betnesol®)
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Green
 
   
Dexamethasone eye drops (Maxidex®)
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Amber Recommended
 
   
Dexamethasone preservative free unit dose
(eye drops)
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Amber Recommended
 
   
Dexamethasone with neomycin and polymyxin B sulphate (Maxitrol®)
(eye ointment)
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Amber Recommended
 
   
Fluocinolone intravitreal implant (Iluvien®)
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Red
High Cost Medicine

Diabetic macular oedema NICE TA 301

 
Link  NICE TA 301 diabetic macular oedema
Link  NICE TA 590 Fluocinolone acetonide intravitreal implant for treating recurrent non-infectious uveitis
   
Fluorometholone eye drops (FML®)
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Amber Recommended

Low potency

 
   
Hydrocortisone sodium phosphate 3.35mg/mL eye drops (Softacort®)
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Amber Initiation
 
   
Loteprednol eye drops (Lotemax®)
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Amber Recommended

Low potency

 
   
Prednisolone 0.5% eye drops (Predsol ®)
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Green
 
   
Prednisolone 0.5% preservative free eye drops
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Green
 
   
Prednisolone 1% eye drops  (Pred Forte®)
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Green
 
   
11.04.01  Intravitreal corticosteroids
Dexamethasone intravitreal implant (Ozurdex®)
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Red
High Cost Medicine
 
Link  NICE TA 229 Dexamethasone intravitreal implant for macular oedema secondary to retinal vein occlusion
Link  NICE TA 460 Adalimumab and dexamethasone for treating non-infectious uveitis
Link  NICE TA349: Diabetic Macular Oedema
   
11.04.02  Other anti-inflammatory preparations to top
Adalimumab injection (Imraldi ® Amgevita ® Humira®)
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Red
High Cost Medicine
NHS England
 
Link  NICE TA 460 Adalimumab and dexamethasone for treating non-infectious uveitis
   
Antazoline 0.5% with xylometazoline 0.05% (Otrivine-Antistin®)
(eye drops)
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Green

NHS England low value medication

A prescription for the treatment of mild to moderate hay fever should not routinely be offered in primary care as the condition is appropriate for self-care

 
   
Lodoxamide eye drops (Alomide®)
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Amber Recommended

Ophthalmology recommendation only

 
   
Olopatadine eye drops (Opatanol®)
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Green
 
   
Sodium cromoglicate 2% eye drops
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Green

NHS England low value medication

A prescription for the treatment of mild to moderate hay fever should not routinely be offered in primary care as the condition is appropriate for self-care

 
   
11.05  Mydriatics and cycloplegics
11.05  Antimuscarinics
Atropine 1% eye drops and unit dose eye drops
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Amber Recommended
 
   
Cyclopentolate eye drops and unit dose eye drops
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Amber Recommended

0.5 % and 1% drops and preservative-free unit dose drops (Minims)

 
   
Homatropine eye drops
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Red
 
   
Tropicamide eye drops and unit dose eye drops
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Red

0.5 % and 1% eye drops and preservative-free unit dose eye drops (Minims)

 
   
11.05  Sympathomimetics
Adrenaline 0.1% preservative free
(eye drops)
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Red
 
   
Phenylephrine hydrochloride unit dose eye drops (Minims® )
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Red
 
   
11.06  Treatment of glaucoma
11.06  Beta-blockers to top
Betaxolol (Betoptic®)
(eye drops)
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Amber Recommended
 
   
Timolol 0.25% and 0.5%
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Amber Recommended

Eye dops, eye gel, preservative free unit dose eye drops

 
   
11.06  Prostaglandin analogues
Bimatoprost (Lumigan®)
(eye drops)
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Amber Recommended

Second line after latanoprost.

 

0.1mg per ml (100mcg per ml) available in 3ml bottles

 

0.3mg per ml (300mcg per ml) available in single dose containers only

 

 

 
   
Bimatoprost with Timolol (Ganfort®)
(eye drops)
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Amber Recommended
 
   
Latanoprost
(eye drops)
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Amber Recommended

First line

 
   
Latanoprost 0.005% with Timolol 0.5% (generic)
(eye drops)
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Amber Recommended
 
   
Latanoprost 50micrograms/mL + timolol 5mg/mL (Fixapost®)
(Preservative free eye drops)
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Amber Recommended
 
   
Latanoprost Preservative Free (Monopost®)
(eye drops)
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Amber Recommended

First choice where a preservative-free prostaglandin analogue is required

 
   
Tafluprost (Preservative Free) 15micrograms/ml (Saflutan®)
(eye drops)
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Amber Recommended
 
   
Tafluprost and Timolol (Taptiqom®)
(eye drops)
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Amber Recommended

Preservative-free drops in single dose containers.

 

Only for use where preservative-free combination treatment is indicated.

 
   
Travoprost (Travatan®)
(eye drops)
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Amber Recommended
 
   
Travoprost with Timolol (DuoTrav®)
(eye drops)
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Amber Recommended
 
   
11.06  Sympathomimetics
Brimonidine Tartrate (generic)
(eye drops)
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Amber Recommended
 
   
Brimonidine Tartrate 0.2% with Timolol 0.5% (Combigan®)
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Amber Recommended
 
   
11.06  Carbonic anhydrase inhibitors and systemic drugs
Acetazolamide (Diamox®)
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Amber Initiation

Tablets

 

SR capsules

 
   
Brinzolamide (generic)
(eye drops)
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Amber Recommended

May be better tolerated than dorzolamide

 
   
Brinzolamide 1% with Timolol 0.5%  (Azarga®)
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Amber Recommended
 
   
Brinzolamide 10mg/ml & brimonidine 2mg/ml (Simbrinza®)
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Amber Recommended
 
   
Dorzolamide (generic)
(eye drops)
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Amber Recommended
 
   
Dorzolamide 2% with timolol 0.5% (Cosopt iMulti)
(Preservative free eye drop)
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Amber Recommended
 
   
Dorzolomide 2% with Timolol 0.5% (generic)
(eye drops)
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Amber Recommended
 
   
11.06  Miotics
Pilocarpine
(eye drops)
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Amber Recommended
 
   
11.07  Local anaesthetics to top
Controlled Drug Cocaine 4% eye drops
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Red
 
   
Lidocaine 4% with fluorescein 0.25% unit dose eye drops (Minims®)
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Formulary
Red
 
   
Oxybuprocaine unit dose eye drops (Minims® )
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Formulary
Red
 
   
Proxymetacaine unit dose eye drops (Minims®)
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Red
 
   
Tetracaine unit dose eye drops (Minims® )
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Formulary
Red

0.5% and 1%

 
   
11.08  Miscellaneous ophthalmic preparations
11.08.01  Tear deficiency, ocular lubricants, and astringents
Sodium Chloride 5% eye drops and ointment
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Amber Recommended
 
   
Acetylcysteine 5% with Hypromellose 0.35% (Ilube®)
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Amber Recommended
 
   
Carbomer 980 gel (eye drops) (Clinitas®, Viscotears®)
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Restricted Drug Restricted
Green

NHS England low value medication

A prescription for treatment of dry or sore eyes should not routinely be offered in primary care as the condition is appropriate for self-care.

 
   
Carmellose sodium 0.5% eye drops (Optive Fusion®, Optive Plus®)
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Restricted Drug Restricted
Green

Optive Plus contains castor oil in addition to carmellose and glycerol

Optive Fusion contains hyaluronic acid in addition to carmellose and glycerol

NHS England low value medication

A prescription for treatment of dry or sore eyes should not routinely be offered in primary care as the condition is appropriate for self-care.

 
   
Carmellose unit dose eye drops (Celluvisc®)
(0.5% and 1% preservative free)
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Restricted Drug Restricted
Green

NHS England low value medication

A prescription for treatment of dry or sore eyes should not routinely be offered in primary care as the condition is appropriate for self-care.

 
   
Hydroxyethylcellulose unit dose drops (Minims® Artificial Tears)
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Restricted Drug Restricted
Green

NHS England low value medication

A prescription for treatment of dry or sore eyes should not routinely be offered in primary care as the condition is appropriate for self-care.

 
   
Hypromellose 0.3% eye drops and preservative-free eye drops
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Restricted Drug Restricted
Green

NHS England low value medication

A prescription for treatment of dry or sore eyes should not routinely be offered in primary care as the condition is appropriate for self-care.

 
   
Macrogols eye drops (Systane®)
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Restricted Drug Restricted
Green

Eye drops, Unit dose drops, Systane Balance

 
   
Polyvinyl alchohol 1.4% eye drops (SnoTears®)
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Restricted Drug Restricted
Green

NHS England low value medication

A prescription for treatment of dry or sore eyes should not routinely be offered in primary care as the condition is appropriate for self-care.

 
   
Sodium hyaluronate 0.1% eye drops (Hylo-Tear®)
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Restricted Drug Restricted
Green

NHS England low value medication

A prescription for treatment of dry or sore eyes should not routinely be offered in primary care as the condition is appropriate for self-care.

 
   
sodium hyaluronate 0.15% eye drops  (Artelac Rebalance®)
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Restricted Drug Restricted
Green

NHS England low value medication

A prescription for treatment of dry or sore eyes should not routinely be offered in primary care as the condition is appropriate for self-care.

 
   
Sodium hyaluronate 0.2% eye drops (Hylo-Forte®)
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Restricted Drug Restricted
Green

NHS England low value medication

A prescription for treatment of dry or sore eyes should not routinely be offered in primary care as the condition is appropriate for self-care.

 
   
Sodium hyaluronate 0.4% eye drops and unit dose eye drops (Clinitas®)
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Restricted Drug Restricted
Green

NHS England low value medication

A prescription for treatment of dry or sore eyes should not routinely be offered in primary care as the condition is appropriate for self-care.

 
   
Sodium hyaluronate with dexpanthenol 2% eye drops (Hylo-Care®)
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Restricted Drug Restricted
Green

NHS England low value medication

A prescription for treatment of dry or sore eyes should not routinely be offered in primary care as the condition is appropriate for self-care.

 
   
White soft paraffin/liquid paraffin eye ointment (Hylo night®, Lacri-Lube®)
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Restricted Drug Restricted
Green

NHS England low value medication

A prescription for treatment of dry or sore eyes should not routinely be offered in primary care as the condition is appropriate for self-care.

VitA-POS is now marketed as HYLO NIGHT

 
   
11.08.02  Ocular diagnostic and peri-operative preparations and photodynamic treatment
11.08.02  Ocular diagnostic preparations
Fluorescein Sodium (Eye drops, injection)
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Red

 


 

 
   
11.08.02  Ocular peri-operative drugs to top
Acetylcholine Chloride (Miochol-E®)
(for intraocular irrigation)
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Formulary
Red
 
   
Apraclonidine (Iopidine®)
(eye drops)
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Formulary
Red

Apraclonidine 0.5% eye drops - short-term adjunctive therapy of chronic glaucoma in patients on maximally tolerated medical therapy who require additional intraocular pressure (IOP) reduction to delay laser treatment or glaucoma surgery.


Apraclonidine 1% single dose - to control or prevent post surgical elevations in intraocular pressure that occur in patients after anterior segment laser surgery.

 
   
Balanced salt solution
(for irrigation)
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Red
 
   
Bromfenac (Yellox®)
(eye drops)
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Formulary
Red
 
   
Ketorolac (Acular®)
(eye drops)
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Formulary
Red
 
   
Nepafenac  (Nevanac®)
(eye drops)
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Formulary
Red

Reduction in the risk of postoperative macular oedema associated with cataract surgery in diabetic patients  - full course to be supplied by hospital.

 
   
Sodium hyaluronate 1% in 1ml (Z-Hyalin®)
(for intraocular use)
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Red
 
   
11.08.02  Subfoveal choroidal neovascularisation
Aflibercept (Eylea®)
(intravitreal injection)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA 294 Aflibercept solution for injection for treating wet age‑related macular degeneration
Link  NICE TA 305 Aflibercept for treating visual impairment caused by macular oedema secondary to central retinal vein occlusion
Link  NICE TA 346 Aflibercept for treating diabetic macular oedema
Link  NICE TA 486 Aflibercept for treating choroidal neovascularisation
Link  NICE TA409: Aflibercept for treating visual impairment caused by macular oedema after branch retinal vein occlusion
   
Ranibizumab (Lucentis®)
(intravitreal injection)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA 155 Ranibizumab and pegaptanib for the treatment of age-related macular degeneration
Link  NICE TA 274 Ranibizumab for treating diabetic macular oedema
Link  NICE TA 283 Ranibizumab for treating visual impairment caused by macular oedema secondary to retinal vein occlusion
Link  NICE TA 298 Ranibizumab for treating choroidal neovascularisation associated with pathological myopia
   
Verteporfin (Visudyne®)
(for infusion)
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Formulary
Red
High Cost Medicine
 
Link  NICE NG82: Age-related macular degeneration
   
11.08.02  Vitreomacular traction
Ocriplasmin (Jetrea®)
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Red
High Cost Medicine
 
Link  NICE TA 297 Ocriplasmin for treating vitreomacular traction
   
11.09  Contact lenses
11.99.99.99  Miscellaneous
11.99.99.99  Cytotoxics / wound healing modulators to top
Holoclar®
(living tissue equivalent)
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Formulary
Red

Ex vivo expanded autologous human corneal cells containing stem cells

 
Link  NICE TA 467 Holoclar for treating limbal stem cell deficiency after eye burns
   
Cytotoxic Drug Mitomycin C intra-ocular injection
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Red

Unlicensed

 
   
11.99.99.99  Fibrinolytic drugs
Alteplase intravitreal injection
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Formulary
Red

Submacular haemorrhage - unlicensed

 
   
11.99.99.99  Glues - ocular
11.99.99.99  Immunosuppressants
Ciclosporin A 0.1% (Verkazia)
(1mg/mL eye drops)
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Formulary
Amber Initiation

For severe keratoconjuctivitis in children from four years of age and adolescents

 
   
Ciclosporin eye drops (Ikervis®)
(Eye)
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Formulary
Amber Recommended
 
Link  NICE TA369 - Ciclosporin for treating eye disease that has not improved despite treatment with artificial tears
   
11.99.99.99  Treatment of burns
Potassium Ascorbate 10% (Ascorbic acid)
(eye drops)
 Track Changes
Formulary
Red

Unlicensed

 
   
Sodium citrate preservative free
(eye drops)
 Track Changes
Formulary
Red

Unlicensed

 
   
11.99.99.99  Visco-elastics to top
11.99.99.99  Other
Disodium edetate 0.37%
(eye drops)
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Formulary
Red
 
   
Glycerol 15% eye drops
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Formulary
Red
 
   
 ....
 Non Formulary Items
Acetazolamide oral liquid

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Non Formulary
 
Amphotericin (intravitreal)

Non Formulary
 
Azelastine  (Optilast®)

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Non Formulary
 
Bethamethasone with Neomycin  (Vista-Methasone-N®)

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Non Formulary
 
Carteolol  (Teoptic®)

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Non Formulary
 
Dexamethasone with tobramycin  (Tobradex®)
(eye drops)

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Non Formulary
 
Diclofenac  (Voltarol® Ophtha)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Dipivefrine Hydrochloride  (Propine®)

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Non Formulary
 
Emedastine  (Emadine®)

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Non Formulary
 
Epinastine  (Relestat®)

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Non Formulary
 
Flurbiprofen Sodium  (Ocufen®)

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Non Formulary
 
Hypromellose 0.3% with Dextran 70 0.1%  (Tears Naturale®)
(eye drops)

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Non Formulary
 
Hypromellose 0.5% eye drops  (Isopto Plain®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary
 
Hypromellose 1% eye drops  (Isopto Alkaline®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary
 
Idebenone  (Raxone®)

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Non Formulary
 
Ketotifen  (Zaditen®)

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Non Formulary
 
Levobunolol  (Betagan®)

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Non Formulary
 
Neodocromil  (Rapitil®)

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Non Formulary
 
Neomycin Eye drops

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Non Formulary
 
Pegaptanib Sodium  (Macugen®)

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Non Formulary
High Cost Medicine

Not recommended by NICE in TA 155

 
Phenylephrine and tropicamide ophthalmic insert  (Mydriasert®)

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Non Formulary

Under evaluation

 
Pilocaprine long acting  (Pilogel®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Rimexolone eye drops  (Vexol®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary

DISCONTINUED

 
Sodium Chloride  (Minims® Saline)

Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Green

Primary and Secondary Care (unrestricted) – may be prescribed by GPs, hospital doctors or other qualified prescribers in primary and secondary care  

Amber Initiation

Amber Initiated: first prescription from specialist, on going supplies from primary care (or when stabilised on therapy).  

Amber Recommended

Amber recommended: first prescription may be supplied by primary care under the advice of a specialist.  

Amber with Shared Care

For initiation within a specialist service followed by ongoing prescribing in primary care according to published shared care guidance  

Red

For initiation and ongoing prescribing in secondary care only. Medicines in this category may be further restricted to use by specific hospital departments only.  

Blue

For prescribing in primary care only  

netFormulary