netFormulary Portsmouth and South East Hampshire NHS
Prescribing Formulary  
 Search
 Formulary Chapter 20: Unlicensed Medicines / approved off-label use - Full Chapter
Notes:

This chapter is still in development.

Some unlicensed medicines and off-licence indications are included in the main BNF chapters - search by drug name.

 Details...
20  Expand sub section  Unlicensed Medicines
Acetic Acid Solution 5%
(Endoscopy)
 Track Changes
Restricted Drug Restricted
Red
 
   
ACETYLCYSTEINE
(Tabs / Caps / Sachets)
 Track Changes
Formulary
Red
 
   
Acetylcysteine tablets
(Pulmonary fibrosis)
 Track Changes
Formulary
Red
 
   
Ajmaline injection
 Track Changes
Restricted Drug Restricted
Red

Consultant cardiologist only for diagnosis of Brugada syndrome

 
   
Artesunate injection
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red

Falciparum malaria - refer to PHT Adult Antimicrobial Guide

 
   
Asparaginase (Medac) Injection 10000 units
 Track Changes
Restricted Drug Restricted
Red
 
   
Beclometasone dipropionate 0.0025% w/w in WSP BP ointment
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Unlicensed special listed on BAD specials list 2018

 
   
Benzbromarone 100mg tablets
 Track Changes
Restricted Drug Restricted
Red

Gout - consultant rheumatologist only

 
   
Benzoin Tincture, Compound, BP
(Friars balsam)
 Track Changes
Formulary
Red
 
   
Bevacizumab intravitreal injection
 Track Changes
Restricted Drug Restricted
Red

Only for neovascular eye conditions not covered by NICE recommendations.

 
   
Clonidine oral solution
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red

Premedication/sedation of children prior to surgery

 
   
Dibotermin Alfa, rhBMP-2 (InductOs®)
(Kit for implant)
 Track Changes
Restricted Drug Restricted
Red

Contact directorate pharmacist for advice/orders


NHS England are responsible for commissioning use in complex spinal surgery at specialist centres (Policy 16063/P)

 
   
Fibrin Sealant (Evicel®)
 Track Changes
Formulary
Red

Restricted Item Information on restriction - Urology - Partial nephrectomy surgery. ENT - pharyngeal resection, named surgeon only.


 

 
   
Glycopyrronium oral solution 5mg in 5ml
 Track Changes
Restricted Drug Restricted
Amber Initiation

For hypersalivation

 

Unlicensed special listed in Drug Tariff

 

Paediatrics only

 
   
Hydroquinone, hydrocortisone and tretinoin (Pigmanorm®)
 Track Changes
Restricted Drug Restricted
Red

Hydroquinone 5% w/w, hydrocortisone 1% w/w and tretinoin 0.1% w/w


Unlicensed in the UK. On BAD specials list for melasma (maximum 6 months treatment).

 
   
Indocyanine Green
(injection)
 Track Changes
Restricted Drug Restricted
Red

Surgical dye

 
   
Ivermectin tablets
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Scabies, in combination with topical drugs, for the treatment of hyperkeratotic (crusted or ‘Norwegian’) scabies that does not respond to topical treatment alone.

 
   
Levamisole 50mg tablets
 Track Changes
Restricted Drug Restricted
Red

Roundworm infections

 
   
Levosimendan for infusion
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red

Critical care only - refer to Drug Therpay Guideline

 
   
Lidocaine/adrenaline/tetracaine (LAT)
(gel)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red

Paediatrics only.

 
   
Methylthioninium chloride (Proveblue®)
(injection )
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Ifosfamide-induced encephalopathy (off-licence)


Vasopressor in septic shock (off-licence)

 
   
Mexiletine capsules
 Track Changes
Restricted Drug Restricted
Red
 
   
Morphine sulfate 10mg in 10ml Intrasite gel
(for topical use)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red

Acute painful skin reactions due to radiotherapy

 
   
Mydricaine No.1 and No.2 injection
 Track Changes
Restricted Drug Restricted
Red
 
   
Oxandrolone tablets 2.5 mg
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red

Unlicensed


Paediatrics only

 
   
Papaverine hydrochloride injection
 Track Changes
Restricted Drug Restricted  
   
Pentoxifylline tablets
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Alcoholic hepatitis - unlicensed use

 
   
Pirenzepine tablets
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red
 
   
Potassium canrenoate injection 200 mg in 10mL
 Track Changes
Restricted Drug Restricted
Red

Unlicensed


Paediatrics only

 
   
Potassium iodide capsules
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red
 
   
Propylene glycol 40% w/w in aqueous cream
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Unlicensed special listed on BAD specials list 2018

 
   
Propylene glycol 50% w/w in water
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Unlicensed special listed on BAD specials list 2018

 
   
Sirolimus 0.1% in WSP
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Unlicensed special listed on BAD specials list 2018

 
   
Sirolimus 0.5% in WSP
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Unlicensed special listed on BAD specials list 2018

 
   
Sodium Hyaluronate 800mg/50mL (1.6%), Sodium Chondroitin Sulfate 1g/50mL (2%) (iAluRil®)
(Bladder instillation)
 Track Changes
Restricted Drug Restricted
Red

Licensed as a medical device


Urology only

 
   
Sodium thiosulfate
(injection )
 Track Changes
Formulary
Red

Calciphylaxis

 
   
Sucralfate 4% in emulsifying ointment
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Unlicensed special listed on BAD specials list 2018

 
   
Tacrolimus 0.1% and 0.03% in Orabase
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Used for ulcerative and erosive inflammatory skin disease including around stomas.

 

Unlicensed special on BAD list.

 

 

 
   
TALC BP purified sterile
 Track Changes
Restricted Drug Restricted
Red

For talc pleurodesis - refer to PHT Drug Therapy Guideline

 
   
Triamcinolone 0.1% in Orabase
 Track Changes
Formulary
Amber Initiation

Used for ulcerative and erosive inflammatory skin disease including around stomas.

 

 

 

Unlicensed special on BAD list.

 
   
TROMETAMOL (THAM) 125ML Injection 3.6% (0.3M)
 Track Changes
Unlicensed Drug Unlicensed
Red

Paediatric Use Only

 
   
 ....
 Non Formulary Items
Eptotermin Alfa  (Osigraft®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary
High Cost Medicine

Product withdrawn

 

 

 
Glycopyrronium tablets  (Hyperhidrosis)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
NeilMed Sinus Rinse

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Pollinex Quattro®

Non Formulary
 
Sodium hyaluronate  (Cystistat®)
(bladder instillation)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sodium hyaluronate  (Hyacyst®)
(bladder instillation)

Track Changes
Non Formulary
 
Sodium hyaluronate injection  (SportVis®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Spectinomycin Injection 2 g

Track Changes
Non Formulary
 
Sucralfate 2g/50ml enema

Track Changes
Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Green

Primary and Secondary Care (unrestricted) – may be prescribed by GPs, hospital doctors or other qualified prescribers in primary and secondary care  

Amber Initiation

Amber Initiated: first prescription from specialist, on going supplies from primary care (or when stabilised on therapy).  

Amber Recommended

Amber recommended: first prescription may be supplied by primary care under the advice of a specialist.  

Amber with Shared Care

For initiation within a specialist service followed by ongoing prescribing in primary care according to published shared care guidance  

Red

For initiation and ongoing prescribing in secondary care only. Medicines in this category may be further restricted to use by specific hospital departments only.  

Blue

For prescribing in primary care only  

netFormulary