netFormulary Portsmouth and South East Hampshire NHS
Prescribing Formulary  
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 Formulary Chapter 4: Central nervous system - Full Chapter
04.01  Hypnotics and anxiolytics
04.01.01  Hypnotics
Melatonin (Paediatrics)
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Restricted Drug Restricted
Amber with Shared Care

CAMHS / Community Paediatrics only if sleep hygiene measures have failled. 

 

2mg m/r (Circadin) first line, but off license.  Unlicensed tablets/capsules second line - a brand name must be specified.  Kidnaps oral suspension 1mg in 1ml (unlicensed) if liquid required

 
Link  Melatonin for sleep disorders in children shared care agreement
   
04.01.01  Benzodiazepines
Controlled Drug Midazolam injection
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Formulary
Green

by subcutaneous injection for symptom control in palliative care

 
   
Nitrazepam
(tablets, oral suspension)
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Formulary
Green

Short term use only

 
   
Controlled Drug Temazepam
(tablets, oral solution)
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Formulary
Green

Short term use only

 
   
04.01.01  Zaleplon, Zolpidem and Zopiclone
Zolpidem
(tablets)
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Formulary
Green

Short term use only

 
Link  NICE TA77: Zaleplon, zolpidem and zopiclone for the management of insomnia
   
Zopiclone
(tablets)
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Formulary
Green

Short term use only

 
Link  NICE TA77: Zaleplon, zolpidem and zopiclone for the management of insomnia
   
04.01.01  Chloral and derivatives to top
Chloral Betaine
(tablets)
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Formulary
Green

For use in pregnancy.


Note HIGH COST in primary care.

 
   
Chloral Hydrate
(oral solution)
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Formulary
Green

Note HIGH COST in primary care

 
   
04.01.01  Clomethiazole (Chlormethiazole)
Clomethiazole
(capsules, oral solution)
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Formulary
Green
 
   
04.01.01  Antihistamines
04.01.01  Alcohol
04.01.01  Sodium oxybate
04.01.02  Anxiolytics to top
04.01.02  Benzodiazepines
Chlordiazepoxide
(Capsules)
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Formulary
Green

Alcohol withdrawal

 
   
Diazepam
(tablets, oral solution)
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Formulary
Green

Short term use only

 
   
Lorazepam
(tablets)
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Formulary
Green

Short term use only

 
   
Lorazepam
(injection)
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Formulary
Red
 
   
04.01.02  Buspirone
Buspirone Hydrochloride
(Tablets)
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Restricted Drug Restricted
Red

For use by Southern Health as per the anxiety treatment guidelines only

 
   
04.01.02  Beta blockers
04.01.02  Meprobamate
04.01.03  Barbiturates to top
04.02  Drugs used in psychoses and related disorders
04.02.01  Antipsychotic Drugs
Benperidol (Anquil®)
(tablets)
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Formulary
Amber Initiation

Psychiatry only

 

Note HIGH COST in primary care

 
   
Chlorpromazine
(tablets, oral solution)
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Formulary
Green
 
   
Flupentixol (Depixol®)
(tablets)
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Formulary
Green
 
   
Haloperidol
(tablets, oral solution, injection)
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Green
 
   
Levomepromazine (methotrimeprazine)
(tablets, injection)
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Formulary
Green

Prescribe as 25mg tablets - these can be divided to provide 6.25mg or 12.5 mg oral doses.


6mg tablets are only available as an unlicensed special at HIGH COST in primary care.

 
   
Pimozide (Orap®)
(tablets)
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Formulary
Green
 
   
Promazine Hydrochloride
(tablets, oral solution)
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Formulary
Green
 
   
Sulpiride
(tablets, oral solution)
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Formulary
Green
 
   
Trifluoperazine
(tablets, oral solution)
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Formulary
Green
 
   
Zuclopenthixol (Clopixol®)
(tablets)
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Formulary
Green
 
   
Zuclopenthixol Acetate (Clopixol Acuphase®)
(Injection)
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Formulary
Red

Psychiatry only

 
   
04.02.01  First-Generation Antipsychotic Drugs
04.02.01  Second-Generation Antipsychotic Drugs
Amisulpride
(tablets)
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Formulary
Amber Recommended
 
   
Aripiprazole
(tablets)
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Formulary
Amber Recommended

First line if hyperprolactinaemia caused by other agents.  Schizophrenia in 15-17 year olds (second line) NICE TA 213.  Manic episodes in bipolar disorder in adolescents over 13 NICE TA 292

 
Link  NICE TA213: Aripiprazole for the treatment of schizophrenia in people aged 15 -17 years
Link  NICE TA292: Bipolar disorder (children) - aripiprazole
   
Clozapine
(tablets)
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Restricted Drug Restricted
Red

Specialist use only.  Special requirements for monitoring.

 
   
Olanzapine
(tablets, orodispersible tablets)
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Formulary
Green
 
   
Olanzapine 10mg injection
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Restricted Drug Restricted
Red

Only for use in accordance with rapid tranquilisation guidelines

 
   
Quetiapine
(tablets)
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Formulary
Green

Immediate release only

 
   
Quetiapine XL
(modified release tablets)
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Formulary
Amber Recommended

Generic immediate release tablets are first line - refer to guidance from Solent NHS Trust and Southern Health NHS FT

 

Most cost effective brand in primary care is Sondate XL

 
   
Risperidone
(tablets, oral solution)
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Formulary
Green
 
   
04.02.02  Antipsychotic depot injections to top
Aripiprazole (Abilify Maintena®)
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Formulary
Red

Southern Health NHS FT and Solent NHS Trust psychiatrists only

 
   
Flupentixol Decanoate (Depixol®)
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Formulary
Amber Initiation

Psychiatry only

 
   
Flupentixol Decanoate (Depixol® Conc.)
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Formulary
Amber Initiation

Psychiatry only

 
   
Flupentixol Decanoate (Depixol® Low Volume)
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Formulary
Amber Initiation

Psychiatry only

 
   
Fluphenazine decanoate injection (Modecate®)
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Formulary
Red

Modecate is going to be discontinued and will no longer be available after the end of 2018.


New patients should not be initiated on Modecate and existing patients will need to be identified and an alternative treament prescribed.

 
   
Haloperidol (Haldol Decanoate®)
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Formulary
Amber Initiation

Psychiatry only

 
   
Paliperidone palmitate  (Trevicta®)
(Prolonged release suspension for injection)
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Formulary
Red

3-monthly depot


Southern Health NHS FT and Solent NHS Trust psychiatrists only

 
   
Paliperidone palmitate  (Xeplion®)
(Prolonged release suspension for injection)
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Formulary
Red

1-monthly depot


Southern Health NHS FT and Solent NHS Trust psychiatrists only

 
   
Pipotiazine Palmitate (Piportil® Depot)
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Formulary
Amber Initiation

Psychiatry only

 
   
Risperidone (Risperdal Consta®)
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Formulary
Red

Southern Health NHS FT and Solent NHS Trust psychiatrists only

 
   
Zuclopenthixol Decanoate (Clopixol®)
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Formulary
Amber Initiation

Psychiatry only

 
   
Zuclopenthixol Decanoate (Clopixol® Conc.)
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Formulary
Amber Initiation

Psychiatry only

 
   
04.02.03  Drugs used for mania and hypomania
Pregabalin
(Anxiety)
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Formulary
Green
 
   
04.02.03  Benzodiazepines
04.02.03  Antipsychotic drugs
04.02.03  Carbamazepine
04.02.03  Valproic acid to top
Sodium valproate
(Mania)
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Formulary
Amber Initiation
 
   
Valproic Acid (Depakote®)
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Formulary
Amber Initiation
 
   
04.02.03  Lithium
Lithium Carbonate (Camcolit ® )
(tablets, modified release tablets)
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Formulary
Amber with Shared Care

Prescribe by brand name

 

Green Green      For Portsmouth CCG patients                                                

 
   
Lithium Carbonate (Liskonum®)
(modified release tablets)
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Formulary
Amber with Shared Care

Prescribe by brand name

Green Green      For Portsmouth CCG patients   

 
   
Lithium Carbonate (Priadel®)
(modified release tablets)
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Formulary
Amber with Shared Care

Prescribe by brand name

Green Green      For Portsmouth CCG patients   

 
   
Lithium Citrate (Li-Liquid®)
(oral solution)
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Formulary
Amber with Shared Care

Prescribe by brand name

Green Green      For Portsmouth CCG patients   

 
   
Lithium Citrate (Priadel®Liquid)
(sugar free syrup)
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Formulary
Amber with Shared Care

Prescribe by brand

Green Green      For Portsmouth CCG patients   

 
   
04.03  Antidepressant drugs
04.03.01  Tricyclic and related antidepressant drugs
04.03.01  Tricyclic antidepressants
Amitriptyline
(Tablets)
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Formulary
Green
 
   
Clomipramine
(Capsules)
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Formulary
Green

Psychiatry only: refer to anxiety treatment guidelines

 
   
Doxepin
(Capsules)
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Formulary
Amber Initiation

For dermatology use only - pruritus

 
   
Imipramine
(tablets)
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Formulary
Green

Alternative to amitriptyline for peripheral neuropathic pain in adults - refer to chronic pain guideline

 
   
Lofepramine
(tablets)
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Formulary
Green
 
   
Nortriptyline
(tablets)
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Formulary
Green

Alternative to amitriptyline for peripheral neuropathic pain in adults - refer to chronic pain guideline


Note HIGH COST compared to amitriptyline

 
   
04.03.01  Related antidepressants to top
Trazodone
(tablets, capsules)
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Formulary
Green
 
   
04.03.02  Monoamine-oxidase inhibitors
Phenelzine (Nardil®)
(tablets)
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Formulary
Amber Initiation

Psychiatry only

 
   
Tranylcypromine
(tablets)
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Formulary
Amber Initiation

Psychiatry only

 

Note HIGH  COST in primary care

 
   
04.03.02  Reverible MAOIs
Moclobemide
(tablets)
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Formulary
Amber Initiation

Specialist initiation only

 
   
04.03.03  Selective serotonin re-uptake inhibitors
Fluoxetine
(Capsules, oral solution)
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First Choice
Green

First line agent in general population


20mg capsules are the most cost-effective presentation for doses of 20mg, 40mg and 60mg.


Oral solution 20mg in 5ml can be used for patients with swallowing difficulties or if a 10mg dose is required.

 
Sertraline
(tablets)
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First Choice
Green

First line agent in general population

 
Citalopram
(tablets, oral drops)
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Formulary
Green

Maximum dose 40mg/ day, 20mg in elderly or liver dysfunction.  Refer to MHRA and local advice concerning QQT prolongation

 
   
Escitalopram
(tablets)
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Formulary
Green

Refer to MHRA and local advice concerning QT prolongation and  dose restrictions

 
   
Paroxetine
(tablets, oral suspension)
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Formulary
Green

Not first line agent.  More frequent withhdrawal reactions.  Do not exceed recommended dose.  See CSM Warnings


 

 
   
Vortioxetine (Brintellix®)
(tablets)
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Formulary
Amber Initiation

Major depressive episodes in adults NICE TA 367

 
Link  NICE TA367 - Vortioxetine for treating major depressive episodes
   
04.03.04  Other antidepressant drugs
Agomelatine (Valdoxan®)
(tablets)
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Formulary
Amber Initiation

Refer to mental health provider guidelines

 
   
Duloxetine
(Capsules)
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Formulary
Amber Initiation

Mental Health specialists only to initiate for depression/GAD.

 

 

 
Link  Southern Health Management of Depression in Adults and Older People Guidelines
   
Flupentixol (Fluanxol®)
(tablets)
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Formulary
Amber Recommended
 
   
Mirtazapine
(tablets, orodispersible tablets)
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Formulary
Green

Second line agent

 
   
Venlafaxine
(tablets, modified release tablets)
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Formulary
Green

Only after adequate trial of two alternative antidepressants.  Not for patients with heart disease, including hypertension.  Refer to mental health provider guidelines.

 

Prescribe as immediate release if possible.  Most cost effective brand for modified release in primary care is Vensir XL Capsules

 
   
04.04  CNS stimulants and other drugs used for attention deficit hyperactivity disorder to top
 note 

Children  - shared care with Sussex Partnership NHSFT has been agreed for South Eastern Hampshire and Fareham and Gosport CCG patients - refer to shared care agreement

Adults - service is provided by Surrey and Borders Partnership NHSFT across Hampshire. Shared care guidance is in development.

Atomoxetine (Strattera®)
(Capsules)
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Formulary
Amber with Shared Care

Children - CAMHS initiation only

CAMHS Shared care agreement for Hampshire will be available on iDOCs

Adults - diagnosis and treatment initiation via Hampshire ADHD service (provided by Surrey and Borders Partnership NHSFT)

 

Awaiting shared care guidelines

 
   
Controlled Drug Dexamfetamine
(tablets)
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Formulary
Amber with Shared Care

Children - CAMHS initiation only

CAMHS Shared care agreement for Hampshire will be available on iDOCs

Adults - diagnosis and treatment initiation via Hampshire ADHD service (provided by Surrey and Borders Partnership NHSFT)

 

Awaiting shared care guidelines

 
   
Guanfacine (Intuniv®)
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Formulary
Amber with Shared Care

CAMHS Shared care agreement for Hampshire will be available on iDOCs

 
   
Controlled Drug Lisdexamfetamine (Elvanse®)
(Capsules)
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Formulary
Amber with Shared Care

Children - CAMHS initiation only for ADHD refractory to methylphenidate

CAMHS Shared care agreement for Hampshire will be available on iDOCs

Adults - diagnosis and treatment initiation via Hampshire ADHD service (provided by Surrey and Borders Partnership NHSFT)

 

Awaiting shared care guidelines

 
   
Controlled Drug Methylphenidate
(tablets)
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Formulary
Amber with Shared Care

Children - CAMHS initiation only 

CAMHS Shared care agreement for Hampshire will be available on iDOCs

Adults - diagnosis and treatment initiation via Hampshire ADHD service (provided by Surrey and Borders Partnership NHSFT)

 

Awaiting shared care guidelines

 
   
Controlled Drug Methylphenidate Hydrochloride MR
(modified release tablets)
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Formulary
Amber with Shared Care

Children - CAMHS initiation only

Prefered product is Matoride XL

CAMHS Shared care agreement for Hampshire will be available on iDOCs

Adults - diagnosis and treatment initiation via Hampshire ADHD service (provided by Surrey and Borders Partnership NHSFT)

 

Awaiting shared care guidelines

 
   
Modafinil
(tablets)
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Restricted Drug Restricted
Amber Initiation

Hypersomnolence associated with Parkinson's disease (off-licence)

Excessive sleepiness associated with narcolepsy

 
   
04.04  Cocaine
04.05  Drugs used in the treatment of obesity
04.05.01  Anti-obesity drugs acting on the gastro-intestingal tract
Orlistat
(Capsules)
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Formulary
Blue
 
   
04.05.02  Centrally acting appetite suppressants
04.06  Drugs used in nausea and vertigo to top
Netupitant and Palonosetron (Akynzeo®)
(capsules)
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Formulary
Red

For prevention of chemotherapy induced nausea and vomiting only - refer to CINV guidelines


 

 
   
04.06  Vomiting during pregnancy
04.06  Postoperative nausea and vomiting
04.06  Motion sickness
04.06  Other vestibular disorders
04.06  Cytotoxic chemotherapy to top
04.06  Palliative care
04.06  Migraine
04.06  Antihistamines
Cyclizine
(tablets, injection)
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Formulary
Green
 
   
Cinnarizine
(tablets)
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Restricted Drug Restricted
Green

NHS England low value medication

A prescription for the treatment of travel sickness should not routinely be offered in primary care as the condition is appropriate for self-care.

 
   
Promethazine Hydrochloride (Phenergan)
(tablets, oral solution)
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Restricted Drug Restricted
Green

NHS England low value medication

A prescription for the treatment of travel sickness should not routinely be offered in primary care as the condition is appropriate for self-care.

 
   
04.06  Phenothiazines and related drugs
Chlorpromazine
(tablets, injection, oral solution)
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Formulary
Green
 
   
Droperidol (Xomolix®)
(injection )
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Restricted Drug Restricted
Red

Prevention and treatment of post-operative nausea and vomting in paediatrics.

 
   
Prochlorperazine
(tablets, injection)
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Formulary
Green
 
   
Prochlorperazine (Buccastem® )
(buccal tablets)
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Formulary
Green
 
   
04.06  Domperidone and metoclopramide to top
Domperidone
(tablets, oral suspension)
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Formulary
Green
 
   
Metoclopramide
(tablets, injection, oral solution)
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Formulary
Green
 
   
04.06  5HT3 antagonists
Granisetron
(tablets)
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Formulary
Red

For chemotherapy induced nausea and vomiting

 
   
Ondansetron
(tablets)
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Formulary
Green

Zofran MELTS are non formulary

 
   
04.06  Neurokinin receptor antagonist
Aprepitant (Emend®)
(Capsules)
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Formulary
Red

NHSE funded chemotherapy supportive drug 


PONV following bariatric surgery (off-license)

 
   
Fosaprepitant (Ivemend®)
(for infusion)
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Formulary
Red

NHSE funded chemotherpay supportive drug


Only for patients unable to take any oral antiemetics or with anticipatory nausea and vomiting.

 
   
04.06  Cannabinoid
04.06  Hyoscine
Hyoscine Hydrobromide
(injection)
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Formulary
Green
 
   
Hyoscine Hydrobromide (Kwells)
(tablets)
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Restricted Drug Restricted
Green

NHS England low value medication

A prescription for the treatment of motion sickness should not routinely be offered in primary care as the condition is appropriate for self-care

 
   
Hyoscine hydrobromide (Scopoderm TTS®)
(patches)
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Restricted Drug Restricted
Green

Licensed for motion sickness but used for other unlicensed indications e.g. palliative care

NHS England low value medication

A prescription for the treatment of motion sickness should not routinely be offered in primary care as the condition is appropriate for self-care

 
   
04.06  Other drugs for Ménière's disease to top
Betahistine Dihydrochloride
(tablets)
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Formulary
Green

Meniere's disease

 
   
04.07  Analgesics
04.07.01  Non-opioid analgesics and compound analgesic preparations
04.07.01  Compound analgesic preparations
Aspirin
(tablets, dispersible tablets)
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Formulary
Green

Mild to moderate pain

NHS England low value medication

A prescription for the treatment of minor conditions associated with pain, discomfort and mild fever should not routinely be offered in primary care as the condition is appropriate for self-care. (e.g aches and sprains, headache, period pain, back pain).

 
   
Paracetamol
(tablets, soluble tablets)
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Formulary
Green

Mild to moderate pain

NHS England low value medication

A prescription for the treatment of minor conditions associated with pain, discomfort and mild fever should not routinely be offered in primary care as the condition is appropriate for self-care. (e.g aches and sprains, headache, period pain, back pain).

 
   
Paracetamol and codeine (Co-codamol 30/500)
(tablets, capsules)
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Formulary
Green

Severe pain.  Most cost effective brand in primary care is Zapain

 
   
Paracetamol and codeine (Co-codamol 8/500)
(tablets, effervescent/dispersible tablets)
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Formulary
Green

Mild to moderate pain

NHS England low value medication

A prescription for the treatment of minor conditions associated with pain, discomfort and mild fever should not routinely be offered in primary care as the condition is appropriate for self-care. (e.g aches and sprains, headache, period pain, back pain).

 
   
Paracetamol and dihydrocodeine
(Co-dydramol tablets)
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Formulary
Green

Mild to moderate pain

NHS England low value medication

A prescription for the treatment of minor conditions associated with pain, discomfort and mild fever should not routinely be offered in primary care as the condition is appropriate for self-care. (e.g aches and sprains, headache, period pain, back pain).

 
   
Paracetamol IV (Perfalgan®)
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Formulary
Red
 
   
04.07.02  Opioid analgesics
Controlled Drug Buprenorphine
(sublingual tablets, injection)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended

Moderate to severe pain

 
   
Controlled Drug Buprenorphine transdermal patch (BuTrans®, Butec®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Moderate non-cancer pain requiring an opioid analgesic if other agents by the oral route are not suitable or not tolerated.  

 

Change patch every 7 days. 

 

Prescribe by brand name. In primary care the most cost effective brand is Butec

 
   
Controlled Drug Buprenorphine transdermal patch (Transtec® Bupeaze®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Moderate to severe chronic pain including cancer pain requiring an opioid analgesic where oral morphine is unsuitable or not tolerated.  Palliative care.    

 

Change patch every 4 days. 

 

Prescribe by brand name. In primary care the cost effective brand is Bupeaze

 
   
Codeine Phosphate injection
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
Controlled Drug Injection only
   
Codeine phosphate tablets
(analgesia)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Moderate to severe pain

 
   
Controlled Drug Diamorphine Injection
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Severe pain

 
   
Controlled Drug Diamorphine nasal spray (Ayendi®)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red

For paediatric emergency use only


Refer to Drug Therapy Guideline

 
   
Dihydrocodeine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Non MR tablets only

 
   
Dihydrocodeine MR
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Controlled Drug Fentanyl
(Patch)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Most cost effective brand in primary care is Mezolar Matrix

 
   
Controlled Drug Fentanyl sublingual tablets (Abstral®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended

Incident and breakthrough pain in opioid tolerant cancer patients not responding to usual rescue medications. Prescribe by brand name

 
   
Controlled Drug Morphine sulfate
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Includes MR capsules (Zomorph), sachets, injection, oral solution

 
   
Controlled Drug Oxycodone
(capsules, modified release tablets, injection)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Palliative care second line if intolerant of morphine.  Option for post operative pain if morphine causes hallucinations (acute pain team only - to be supplied as TTO if necessary but not to be continued in primary care).

 

Most cost effective brands in primary care are Shortec (IR) and Longtec (MR)/ Oxeltra (MR)

 
   
Controlled Drug Oxycodone
(capsules, modified release tablets, injection)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Option for post-operative pain in enhanced recovery pathways

 
   
Controlled Drug Papaveretum
(Injection)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Severe pain

 
   
Controlled Drug Pethidine
(tablets, injection)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Green

Severe pain

 
   
Controlled Drug Tapentadol (Palexia®)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Acute pain team only as alternative to oxycodone and only if first-line morphne not tolerated. To be supplied as TTO only if prescribed by acute pain team; not to be continued in primary care


 

 
   
Controlled Drug Tapentadol (Palexia®SR)
(modified release tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

Severe chronic pain, secondline option only when morphine has not provided adequate pain control or cannot be tolerated

 

 

 
   
Controlled Drug Tramadol
(capsules, modified release tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Not first line - refer to Chronic Pain Guidelines.


Immediate release preferred.  


Preferred brand of MR tablets in primary care is Tramulief (twice daily dosage) - prescribe by brand name.

 
   
Controlled Drug Tramadol injection
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
Controlled Drug Tramadol oral solution 50mg in 5ml
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Unlicensed


Paediatrics only

 
   
Controlled Drug Oxycodone/naloxone (Targinact®)
(modified release tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Amber Initiation

Consultant gastroenterologist only for patients with opioid induced intestinal  failure requiring parenteral nutrition.  Not for general prescribing in severe pain.

 
   
04.07.03  Neuropathic pain to top
Amitriptyline
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Baclofen
(tablets, oral solution)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Carbamazepine (Tegretol)
(tablets, modified release tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Trigeminal neuralgia

 
   
Duloxetine
(Capsules)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Gabapentin
(capsules, tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Refer to chronic pain guidelines

 
   
Imipramine
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Alternative to amitriptyline in peripheral neuropathic pain in adults - refer to chronic pain guidelines

 
   
Nortriptyline
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Alternative to amitriptyline for peripheral neuropathic pain in adults


Note HIGH COST in primary care compared to amitriptyline

 
   
Phenytoin
(Neuropathic pain)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Pregabalin
(Capsules)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Secondline if gabapentin effective but not tolerated.  Pain Clinic, Diabetology, Neurology Consultant only in PHT.  Refer to Chronic Pain Guidelines.

 
   
04.07.03  Trigeminal neuralgia
04.07.03  Postherpetic neuralgia
Capsaicin cream (Axsain®)
(Postherpetic neuralgia)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
04.07.03  Chronic facial pain
04.07.04  Antimigraine drugs
04.07.04.01  Treatment of the acute migraine attack to top
04.07.04.01  5HT1 agonists
Sumatriptan
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
First Choice
Blue

Note 50mg tablets available in PHT to aid diagnosis only NOT for routine treatment

 

NHS England low value medicine

A prescription for infrequent mild migraine should not routinely be offered in primary care as the condition is suitable for self-care.

 
Rizatriptan (tablets, orodispersible tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Blue
 
   
Zolmitriptan
(tablets, orodispersible tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Blue

If orodispersible tablets are required prescribe 2.5mg strength

 
   
04.07.04.01  Ergot alkaloids
04.07.04.01  Anti-emetics
04.07.04.01  Other drugs for migrane
04.07.04.02  Prophylaxis of migraine to top
Amitriptyline
(Migraine prophylaxis)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Clonidine
(25mg tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Pizotifen
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Propranolol
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Topiramate
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Botulinum Toxin Type A (Botox®)
(injection)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine

Migraine prophylaxis

 
Link  NICE TA 260 Botulinum toxin type A for the prevention of headaches in adults with chronic migraine
   
04.07.04.03  Cluster headache
04.08  Antiepileptics
04.08.01  Control of epilepsy
04.08.01  Partial seizures with or without secondary generalisation
04.08.01  Generalised seizures to top
04.08.01  Carbamazepine and Oxcarbazepine
Carbamazepine
(epilepsy)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Includes tablets, MR tablets, liquid and suppositories. (Chewtabs discontinued)


Suppositories are HIGH COST in primary care (£120.00 for 5)


MHRA/CHM Advice on switching:


Category 1: ensure patient is maintained on a specific manufacturer's product. 

 
Link  MHRA advice on switching antiepileptic products
   
Oxcarbazepine (Trileptal®)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

MHRA advice on switching:

 

Category 2: need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history.

 
Link  MHRA advice on switching antiepileptic products
   
04.08.01  Ethosuximide
Ethosuximide
(capsules, oral solution)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

Capsules are HIGH COST in primary care

 

MHRA advice on switching:

 

Category 3: usually unnecessary to ensure that patients are maintained on a specific manufacturer's product unless there are specific concerns, such as patient anxiety and risk of confusion or dosing errors.

 
Link  MHRA advice on switching antiepileptic products
   
04.08.01  Gabapentin and pregabalin
04.08.01  Lacosamide
Lacosamide  (Vimpat ® )
(tablets, oral solution)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

Refractory epilepsy only

 

MHRA advice on switching:

 

Category 3: usually unnecessary to ensure that patients are maintained on a specific manufacturer's product unless there are specific concerns, such as patient anxiety and risk of confusion or dosing errors.

 

 

 
Link  MHRA advice on switching antiepileptic products
   
04.08.01  Lamotrigine to top
Lamotrigine
(tablets, dispersible tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

MHRA advice on switching:

 

Category 2: need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history.

 
Link  MHRA advice on switching antiepileptic products
   
04.08.01  Levetiracetam
Brivaracetam (Briviact®)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

Consultant neurologist only to initiate for patients with refractory epilepsy and where other antiepileptics are contraindicated, ineffective or not tolerated.

 

Specialist to establish benefit and stabilise dose before request is made to GP to provide ongoing prescriptions.

 

 

 
   
Levetiracetam
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended

Includes tablets and oral solution

 

MHRA advice on switching:

 

Category 3: usually unnecessary to ensure that patients are maintained on a specific manufacturer's product unless there are specific concerns, such as patient anxiety and risk of confusion or dosing errors.

 
Link  MHRA advice on switching antiepileptic products
   
04.08.01  Perampanel
04.08.01  Phenobarbital and other barbiturates
Controlled Drug Phenobarbital
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Includes tablets and elixir.


Unlicensed alcohol-free liquid formulations may be prescribed in paediatrics.


MHRA Advice on switching:


Category 1: ensure patient is maintained on a specific manufacturer's product. 

 
Link  MHRA advice on switching antiepileptic products
   
Primidone
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

Note HIGH COST in primary care.

 

MHRA Advice on switching:

 

Category 1: ensure patient is maintained on a specific manufacturer's product. 

 
Link  MHRA advice on switching antiepileptic products
   
04.08.01  Phenytoin
Phenytoin
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Includes capsules, tablets, chewable tablets and suspension.


MHRA Advice on switching:


Category 1: ensure patient is maintained on a specific manufacturer's product. 


 

 
Link  MHRA advice on switching antiepileptic products
   
04.08.01  Retigaine to top
04.08.01  Rufinamide
Rufinamide (Inovelon®)
(tablets, oral suspension)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

Adjunctive therapy in the treatment of seizures associated with Lennox-Gastaut syndrome - initiation by paediatric neurology specialist only.

 

MHRA advice on switching:

 

Category 2: need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history.

 
Link  MHRA advice on switching antiepileptic products
   
04.08.01  Rufinamide
04.08.01  Tiagabine
Tiagabine (Gabitril®)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

MHRA advice on switching:

 

Category 3: usually unnecessary to ensure that patients are maintained on a specific manufacturer's product unless there are specific concerns, such as patient anxiety and risk of confusion or dosing errors.

 
Link  MHRA advice on switching antiepileptic products
   
04.08.01  Topiramate
Topiramate
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

MHRA advice on switching:

 

Category 2 - need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history.

 
Link  MHRA advice on switching antiepileptic products
   
04.08.01  Valproate to top
Sodium Valproate
(Epilepsy)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Includes tablets, MR tablets and liquid


MHRA advice on switching:


Category 2 - need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history.

 
Link  Toolkit on the risks of valproate medicines in female patients
Link  MHRA advice on switching between antiepileptic drug products
   
Sodium Valproate injection
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
04.08.01  Vigabatrin
Vigabatrin (Sabril®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

Refractory epilepsy only.  Includes tablets and sachets.

 

MHRA advice on switching:

 

Category 3: usually unnecessary to ensure that patients are maintained on a specific manufacturer's product unless there are specific concerns, such as patient anxiety and risk of confusion or dosing errors

 
Link  MHRA advice on switching antiepileptic products
   
04.08.01  Zonisamide
Zonisamide (Zonegran®)
(capsules)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

Oral suspension 2mg in 1ml (unlicensed) - paediatrics only

 

MHRA advice on switching:

 

Category 2 - need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history.

 
Link  MHRA advice on switching antiepileptic products
   
04.08.01  Benzodiazepines
Clobazam
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

Epilepsy only - SLS

 

MHRA advice on switching:

 

Category 2: need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history.

 
Link  MHRA advice on switching antiepileptic products
   
Clonazepam
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended

MHRA advice on switching:

 

Category 2: need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history.

 
Link  MHRA advice on switching antiepileptic products
   
04.08.01  Other Drugs
Cannabidiol (Epidyolex)
(100mg/mL oral solution)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
High Cost Medicine
NHS England
 
Link  NICE TA614: Cannabidiol with clobazam for treating seizures associated with Dravet syndrome
Link  NICE TA615: Cannabidiol with clobazam for treating seizures associated with Lennox–Gastaut syndrome
   
Perampanel (Fycompa®)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

Consultant neurologist only.

 

MHRA advice on switching:

 

Category 2: need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history.

 
Link  MHRA advice on switching antiepileptic products
Link  NICE CG137: The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care
   
Piracetam (Nootropil®)
(tablets and oral solution)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation
 
Link  NICE CG137: Epilepsies: diagnosis and management
   
Stiripentol (Diacomit®)
(Capsules and Powder sachets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber with Shared Care

For Adults a shared care guideline is awaited

For paediatric patients, Stiripentol is Amber Initiated 

 
Link  NICE CG137: Epilepsies: diagnosis and management
Link  Stiripentol Shared Care Guideline
   
04.08.02  Drugs used in status epilepticus to top
Clonazepam Injection
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
Diazepam Injection
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Diazepam Rectal Tubes
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Midazolam Oromucosal Solution (Buccolam®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Please prescribe using brand name in primary care

 
   
Paraldehyde Rectal Soln
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Paediatrics only, unlicensed special

 
   
Phenytoin Injection
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
04.08.03  Febrile convulsions
04.09  Drugs used in parkinsonism and related disorders
04.09.01  Dopaminergic drugs used in Parkinsons disease
04.09.01  Dopamine receptor agonists
Apomorphine
(injection )
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Consultant only - requires specialist initiation and supervision

 
   
Bromocriptine
(tablets, capsules)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation
 
   
Cabergoline
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation
 
   
Pramipexole
(tablets, modified release tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended

NOT for restless legs syndrome.

Cost effecive brand for prescribing in primary care is Pipexus.

 
   
Ropinirole
(tablets, modified release tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended

Can be used for Parkinson's Disease, restless legs syndrome if initiated by Sleep Clinic or symptom control in renal palliative care (off-license).  MR formulation may improve adherence

Cost effective brand for primary care is Spiroco or Ipinnia

 
   
Rotigotine (Neupro®)
(Transdermal patches)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber with Shared Care
 
Link  Rotigotine shared care guideline February 2019
   
04.09.01  Levodopa to top
Co-Beneldopa (Madopar®)
(capsules, MR capsules, dispersible tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended
 
   
Co-Careldopa (Duodopa®)
(Intestinal gel)
View adult BNF View SPC online View childrens BNF  Track Changes
Restricted Drug Restricted
Red
High Cost Medicine

Specialist use in line with NHSE Commissioning Policy D04/P/e

 
Link   NHSE Policy: Levodopa-Carbidopa Intestinal Gel (LCIG)
   
Co-Careldopa (Sinemet®)
(tablets, modified release tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended
 
   
Levodopa, carbidopa and entacapone (Stalevo® Stanek®)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended

Cost effective brand for prescribing in primary care is Stanek

 
   
04.09.01  Monoamine-oxidase-B inhibitors
Rasagiline
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended
 
   
Selegiline Hydrochloride
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended
 
   
04.09.01  Catachol-O-methyltransferase inhibitors
Entacapone
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended
 
   
Opicapone (Ongentys®)
(capsules)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended

Second-line after Entacapone following consultant clinician decision.

 
   
04.09.01  Amantadine
Amantadine
(Parkinson's)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended

Includes capsules and syrup

 
   
04.09.02  Antimuscarinic drugs used in parkinsonism
Orphenadrine
(oral solution)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended

Orphenadrine tablets have been discontinued. An oral solution 50mg in 5ml is still available.

 
   
Procyclidine
(tablets, oral solution)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Procyclidine
(injection)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
 
   
Trihexyphenidyl (Benzhexol)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended
 
   
04.09.03  Drugs used in essential tremor, chorea, tics, and related disorders to top
Haloperidol
(tablets, capsules, oral solution)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green
 
   
Riluzole
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber with Shared Care
High Cost Medicine
 
Link  NICE TA20: Motor neurone disease - riluzole
Link  Riluzole for amyotrophic lateral sclerosis shared care agreement
   
Tetrabenazine
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Recommended
 
   
04.09.03  Torsion dystonias and other involuntary movements
Botulinum Toxin Type A
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Refer to list of approved indications

 
   
04.10  Drugs used in substance dependence
04.10  Alcohol dependence
04.10  Cigarette smoking
04.10  Opioid dependence to top
Controlled Drug Methadone Hydrochloride
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Substance Misuse Services only

 
Link  NICE TA 114 Methadone and Buprenorphine for management of opioid dependence
   
Naltrexone Hydrochloride (Opizone®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Substance Misuse services only

 
Link  NICE TA 115 Naltrexone for management of opioid dependence
   
04.10.01  Alcohol dependence
Acamprosate (Campral EC®)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber with Shared Care

Maintaining abstinence in alcohol dependence - refer to shared care guidelines

 
Link  Acamprosate for maintaining abstinence in alcohol dependence shared care agreement (PHT ASNS)
   
Disulfiram (Antabuse®)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber with Shared Care

Substance Misuse Service only

 
   
Nalmefene (Selincro®)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Blue

Refer to local pathway

 
Link  NICE TA 325 Reduction of alcohol consumption in alcohol dependence
   
Naltrexone (Adepend®)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber with Shared Care

Alcohol dependence

 
   
04.10.02  Nicotine dependence
Bupropion Hydrochloride (Zyban®)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Blue

As part of smoking cessation programme

 
   
Nicotine Replacement Therapy
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Includes all formulations and brands


Primary Care -  as part of smoking cessation programme.


Secondary care  - refer to PHT NRT guideline (only a limited range of NRT products are stocked at PHT)

 
   
Varenicline (Champix®)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Green

Option for adults as part of smoking cessation programme

 
Link  NICE TA123: Varenicline
   
04.10.03  Opioid dependence
Controlled Drug Buprenorphine
(sublingual tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber with Shared Care

Opioid dependence

Awaiting shared care guideline

 
   
04.10.03  Opioid substitution therapy
Controlled Drug Buprenorphine and Naloxone (Suboxone®)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Substance Misuse services only

 
   
Controlled Drug Methadone 1mg/ml
(oral solution)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Substance Misuse services only

 
   
04.10.03  Adjunctive therapy and symptomatic treatment to top
Lofexidine (BritLofex®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

Substance Misuse Services only

 
   
04.10.03  Opioid-receptor antagonists
Naltrexone (Nalorex®)
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red

opioid dependence

 
Link  NICE TA115: Drug misuse - naltrexone
   
04.11  Drugs for dementia
Donepezil
(tablets)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

Alzheimers Disease

Dementia associated with Parkinsons disease or Lewy bodies - Priorities Committee Policy Statement 25

 

 

 
   
Galantamine
(tablets, capsules, oral solution)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

Alzheimers Disease

Dementia associated with Parkinsons disease or Lewy bodies - Priorities Committee Policy Statement 25

Cost effective brands for prescribing in primary care are Galazemic or Gazylan XL

 

 
   
Memantine
(tablets, oral solution)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber with Shared Care

Moderate and severe Alzheimers Disease.

 

Dementia associated with Parkinsons disease or Lewy bodies - Priorities Committee Policy Statement 25

 

Shared Care Guideline awaited

 

 

 
   
Rivastigmine
(capsules, oral solution, transdermal patches)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber Initiation

Alzeimers Disease

Dementia associated with Parkinsons disease or Lewy bodies - Priorities Committee Policy Statement 25

 Cost effective brand for prescribing in primary care is Alzest

 

 
   
 ....
 Non Formulary Items
Almotriptan  (Almogran®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary
 
Alprazolam  (Xanax®)

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Non Formulary
 
Controlled Drug  Amobarbital (amylobarbitone) and secobarbital (quinalbarbitone)  (Tuinal®)

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Non Formulary
 
Controlled Drug  Amobarbital (amylobrbitone)  (Sodium Amytal®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Asenapine
(Sycrest)

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Non Formulary
 
Aspirin  (Caprin®)

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Non Formulary
 
Aspirin  (Nu-Seals® Aspirin)

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Non Formulary
 
Aspirin and codeine  (Co-codaprin®)

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Non Formulary
 
Botulinum Toxin Type B  (NeuroBloc®)

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Non Formulary
 
Buspirone Hydrochloride  (Buspar®)

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Non Formulary
 
Controlled Drug  Butobarbital (butobarbitone)  (Soneryl®)

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Non Formulary
 
Carbamazepine
(Dementia)

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Non Formulary
 
Carbamazepine
(mania)

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Non Formulary
 
Chlorpromazine Hydrochloride  (Largactil®)

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Non Formulary
 
Cinnarizine  (Stugeron®)

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Non Formulary
 
Cinnarizine and Dimenhydrinate  (Arlevert®)

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Non Formulary
 
Citalopram  (Cipramil®)

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Non Formulary
 
Clonazepam
(Mania)

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Non Formulary
 
Clonidine Hydrochloride  (Dixarit®)

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Non Formulary
 
Clozapine  (Denzapine®)

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Non Formulary
 
Clozapine  (Zaponex®)

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Non Formulary
 
Co-proxamol

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Non Formulary
 
Dihydrocodeine Tartrate  (DF 118 Forte®)

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Non Formulary

Controlled Drug Injection Only
 
Controlled Drug  Dipipanone  (Diconal®)

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Non Formulary
 
Domperidone  (Motilium®)

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Non Formulary
 
Dosulepin
(tablets, capsules)

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Non Formulary

Non-formulary for new patients from June 2018

 
Eletriptan  (Relpax®)

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Non Formulary
 
Ergotamine Tartrate  (Migril®)

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Non Formulary
 
Eslicarbazepine  (Zebinix®)

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Non Formulary
 
Controlled Drug  Fentanyl
(Actiq lozenges)

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Non Formulary
 
Controlled Drug  Fentanyl  (Effentora® buccal tablets)

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Non Formulary
 
Controlled Drug  Fentanyl  (Instanyl® nasal spray)

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Non Formulary
 
Controlled Drug  Fentanyl Buccal Film  (Breakyl)

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Non Formulary
 
Controlled Drug  Fentanyl Nasal Spray  (PecFent®)

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Non Formulary
 
Fluoxetine  (Prozac®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Fluoxetine TABLETS
(unlicensed special)

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Non Formulary
 
Flurazepam  (Dalmane®)

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Non Formulary
 
Fluvoxamine Maleate  (Faverin®)

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Non Formulary
 
Fluvoxamine Maleate  (Fluvoxamine®)

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Non Formulary
 
Fosphenytoin Sodium  (Pro-Epanutin®)

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Non Formulary
 
Frovatriptan  (Migard®)

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Non Formulary
 
Granisetron transdermal patch  (Sancuso®)
(3.1mg/24hrs)

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Non Formulary
 
Controlled Drug  Hydromorphone  (Palladone®)

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Non Formulary
 
Controlled Drug  Hydromorphone Hydrochloride  (Palladone® SR)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Isocarboxazid

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Non Formulary
 
Isometheptene Mucate  (Midrid®)

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Non Formulary
 
Lamotrigine

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Non Formulary
 
Liraglutide  (Saxenda®)

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Non Formulary
 
Loprazolam

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Non Formulary
 
Lurasidone  (Latuda®)

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Non Formulary
 
Melatonin
(Cluster headache)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Melatonin  (Colonis®)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary

The company has issued a statement confirming that the product is not suitable for use in children. This corresponds with information within the SPC.

 
Controlled Drug  Meprobamate

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Meptazinol  (Meptid®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Methoxyflurane  (Penthrox®)

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Non Formulary
 
Controlled Drug  Methylphenidate Hydrochloride  (Equasym® XL)

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Non Formulary
 
Controlled Drug  Methylphenidate Hydrochloride  (Ritalin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Mianserin

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Non Formulary
 
Mirtazapine  (Zispin® SolTab)

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Non Formulary
 
Controlled Drug  Morphine and cyclizine  (Cyclimorph®)

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Non Formulary
 
Controlled Drug  Morphine Salts  (Sevredol®)

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Non Formulary
 
Nabilone

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Non Formulary
 
Naltrexone/ bupropion  (Mysimba®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Naratriptan  (Naramig®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Nefopam

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Nicotine  (e-Voke®)
(E-cigarette)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Olanzapine Embonate  (ZypAdhera®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Ondansetron  (Zofran®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Oxazepam

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Non Formulary
 
Paliperidone  (Invega®)
(m/r tablets)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary
 
Palonosetron  (Aloxi®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Controlled Drug  Papaveretum
(Papaveretum with hyoscine injection)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Paracetamol  (Panadol OA®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Paracetamol and dihydrocodeine  (Remedeine®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Paroxetine  (Seroxat®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Controlled Drug  Pentazocine

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Pergolide

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Pericyazine

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary
 
Perphenazine  (Fentazin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Controlled Drug  Phenobarbital injection

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Piracetam  (Nootropil®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Pitolisant  (Wakix®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Pizotifen  (Sanomigran®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Promethazine teoclate  (Avomine®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Promethazine Teoclate  (Avomine®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Reboxetine  (Edronex®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Retigabine  (Trobalt®)
(Tablets)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary

Retigabine (Trobalt) tablets discontinued in June 2017.


 

Link  NICE TA232: Retigabine for the adjunctive treatment of adults with partial onset seizures in epilepsy with and without secondary generalisation
 
Rimonabant  (Acomplia®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Rizatriptan  (Maxalt®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Safinamide  (Xadago®)
(tablets)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary
 
Controlled Drug  Secobarbital (quinalbarbitone)  (Seconal Sodium® )

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Selegiline Hydrochloride  (Zelapar®)
(orodispersible tablets)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary
 
Sertindole  (Serdolect®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sertraline  (Lustral®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sibutramine Hydrochloride  (Reductil®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Controlled Drug  Sodium Oxybate  (Xyrem®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
Sodium valproate
(Migraine prophylaxis)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sufentanil  (Zalviso®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sumatriptan  (Imigran®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sumatriptan  (Imigran® Radis)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Tasimelteon  (Hetlioz®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Tolcapone  (Tasmar®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Controlled Drug  Tramadol Hydrochloride and paracetamol  (Tramacet®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Trimipramine
(tablets, capsules)

View adult BNF View SPC online View childrens BNF Track Changes
Non Formulary
 
Valproic acid  (Convulex®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Venlafaxine  (Efexor® XL)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Zaleplon  (Sonata®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Ziprasidone  (Zeldox®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Zotepine  (Zoleptil®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Green

Primary and Secondary Care (unrestricted) – may be prescribed by GPs, hospital doctors or other qualified prescribers in primary and secondary care  

Amber Initiation

Amber Initiated: first prescription from specialist, on going supplies from primary care (or when stabilised on therapy).  

Amber Recommended

Amber recommended: first prescription may be supplied by primary care under the advice of a specialist.  

Amber with Shared Care

For initiation within a specialist service followed by ongoing prescribing in primary care according to published shared care guidance  

Red

For initiation and ongoing prescribing in secondary care only. Medicines in this category may be further restricted to use by specific hospital departments only.  

Blue

For prescribing in primary care only  

netFormulary